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Preheat the oven to 425.
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Pound chicken using a meat mallet until it’s ½-¾ inch thick. Cut into equal-sized 5-ounce portions if they aren’t already.
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Whisk together the eggs, milk, flour, hot sauce, ½ teaspoon salt, and ¼ teaspoon pepper in a large bowl. Add the chicken and toss until it’s well coated.
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Add the panko crumbs, garlic powder, onion powder, paprika, 1 ½ teaspoons of salt, and ½ teaspoon of black pepper to a large shallow bowl. Toss until it’s well mixed.
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Remove one chicken portion at a time from the egg mixture and let any excess drip off. Add it to the Panko crumbs and completely coat it, pressing in the crumbs on both sides. Repeat this with the remaining chicken breasts.
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Place the coated chicken on a large baking sheet that has been lined with parchment paper. Bake for 20-22 minutes or until the chicken is cooked through and no longer pink.